TRANSLATIONAL PHYSIOLOGY Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction
نویسندگان
چکیده
Xiaoli Liu,* Jeremy A. Simpson,* Keith R. Brunt, Christopher A. Ward, Sean R. R. Hall, Robert T. Kinobe, Valerie Barrette, M. Yat Tse, Stephen C. Pang, Alok S. Pachori, Victor J. Dzau, Kofo O. Ogunyankin, and Luis G. Melo Department of Physiology and Department of Anatomy and Cell Biology, Queen’s University, Kingston, Ontario, Canada; Department of Medicine, Duke University Medical Center, Durham, North Carolina; and Department of Medicine, Queen’s University, Kingston, Ontario, Canada
منابع مشابه
Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction.
We reported previously that predelivery of heme oxygenase-1 (HO-1) gene to the heart by adeno-associated virus-2 (AAV-2) markedly reduces ischemia and reperfusion (I/R)-induced myocardial injury. However, the effect of preemptive HO-1 gene delivery on long-term survival and prevention of postinfarction heart failure has not been determined. We assessed the effect of HO-1 gene delivery on long-t...
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Increased production of reactive oxygen species contributes to the etiology of diabetes complications. Pathophysiological stimuli that increase oxidative stress upregulate heme oxygenase (HO)-1, a cytoprotective heme-degrading enzyme. We hypothesized that HO-1 may be important in myocardial injury that is exacerbated by diabetes. To test this hypothesis, the left anterior descending coronary ar...
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تاریخ انتشار 2007